Drug interactions
Apalutamide + Ondansetron
Severity: Moderate
Apalutamide and Ondansetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong CYP3A4 inducer and can lower ondansetron exposure. The antiemetic effect may be reduced, though ondansetron is also cleared by other CYP enzymes, so the effect is moderate.
What this interaction means in plain words
Apalutamide and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Induction of CYP3A4 (and other enzymes) increases ondansetron metabolism.
What to do
Monitor for reduced antiemetic efficacy and consider a higher dose or an alternative antiemetic if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Ondansetron?
MediHelp rates the interaction as moderate. Apalutamide and Ondansetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong CYP3A4 inducer and can lower ondansetron exposure. The antiemetic effect may be reduced, though ondansetron is also cleared by other CYP enzymes, so the effect is moderate.
How serious is the interaction between Apalutamide and Ondansetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiemetic efficacy and consider a higher dose or an alternative antiemetic if control is inadequate.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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