Drug interactions
Apalutamide + Rucaparib
Severity: Minor
Apalutamide and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak inhibitor of CYP3A4 and could modestly raise apalutamide exposure, but apalutamide is also cleared by CYP2C8 and the effect is expected to be small. Apalutamide itself is a potent CYP3A4 inducer, but it is not expected to alter rucaparib clearance meaningfully through that route.
What this interaction means in plain words
Apalutamide and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 (and CYP2C8) by rucaparib may slightly reduce apalutamide metabolism.
What to do
No dose adjustment is usually needed; monitor for apalutamide adverse effects such as rash, fatigue and falls.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Apalutamide with Rucaparib?
MediHelp rates the interaction as minor. Apalutamide and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak inhibitor of CYP3A4 and could modestly raise apalutamide exposure, but apalutamide is also cleared by CYP2C8 and the effect is expected to be small. Apalutamide itself is a potent CYP3A4 inducer, but it is not expected to alter rucaparib clearance meaningfully through that route.
How serious is the interaction between Apalutamide and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor for apalutamide adverse effects such as rash, fatigue and falls.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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