Drug interactions
Apalutamide + Ruxolitinib
Severity: Moderate
Apalutamide and Ruxolitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower ruxolitinib exposure, but active metabolites partly offset this. The clinical effect is usually modest.
What this interaction means in plain words
Apalutamide and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Ruxolitinib belongs to Oncology.
Why it happens
CYP3A4 induction increases ruxolitinib clearance.
What to do
Monitor blood counts and clinical response, and adjust the ruxolitinib dose if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Apalutamide with Ruxolitinib?
MediHelp rates the interaction as moderate. Apalutamide and Ruxolitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may lower ruxolitinib exposure, but active metabolites partly offset this. The clinical effect is usually modest.
How serious is the interaction between Apalutamide and Ruxolitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and clinical response, and adjust the ruxolitinib dose if efficacy declines.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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