Drug interactions
Apalutamide + Trazodone
Severity: Moderate
Apalutamide and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong inducer of CYP3A4 and can substantially lower trazodone plasma concentrations. This may lead to reduced antidepressant or hypnotic effect.
What this interaction means in plain words
Apalutamide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Trazodone belongs to Central Nervous System.
Why it happens
Apalutamide induces CYP3A4, increasing the metabolism of trazodone to its metabolite m-CPP and lowering parent drug exposure.
What to do
Monitor for loss of trazodone efficacy and titrate the dose upward as needed within the labeled range. Consider an alternative antidepressant if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Trazodone?
MediHelp rates the interaction as moderate. Apalutamide and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong inducer of CYP3A4 and can substantially lower trazodone plasma concentrations. This may lead to reduced antidepressant or hypnotic effect.
How serious is the interaction between Apalutamide and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of trazodone efficacy and titrate the dose upward as needed within the labeled range. Consider an alternative antidepressant if response is inadequate.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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