Drug interactions
Apalutamide + Trimipramine
Severity: Moderate
Apalutamide and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide induces several metabolizing enzymes, including CYP3A4 and CYP2C19, which clear trimipramine. Exposure to trimipramine can fall, and antidepressant efficacy may be lost or reduced.
What this interaction means in plain words
Apalutamide and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Trimipramine belongs to Central Nervous System.
Why it happens
Apalutamide induction of CYP2C19 and CYP3A4 increases the hepatic metabolism of trimipramine.
What to do
Watch for loss of antidepressant response and consider a trimipramine dose increase guided by clinical response or plasma levels. Re-evaluate the dose if apalutamide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Trimipramine?
MediHelp rates the interaction as moderate. Apalutamide and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide induces several metabolizing enzymes, including CYP3A4 and CYP2C19, which clear trimipramine. Exposure to trimipramine can fall, and antidepressant efficacy may be lost or reduced.
How serious is the interaction between Apalutamide and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for loss of antidepressant response and consider a trimipramine dose increase guided by clinical response or plasma levels. Re-evaluate the dose if apalutamide is stopped.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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