Drug interactions
Apalutamide + Vortioxetine
Severity: Moderate
Apalutamide and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is a strong inducer of CYP3A4 and other enzymes, and can substantially lower vortioxetine concentrations. This may lead to loss of antidepressant effect and relapse.
What this interaction means in plain words
Apalutamide and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Vortioxetine belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 (and other CYP enzymes) increases the hepatic clearance of vortioxetine.
What to do
Monitor for reduced antidepressant response and consider increasing vortioxetine, up to about three times the original dose per labeling for strong inducers, but not above the maximum recommended dose. Reduce the dose back within 14 days if the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Vortioxetine?
MediHelp rates the interaction as moderate. Apalutamide and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is a strong inducer of CYP3A4 and other enzymes, and can substantially lower vortioxetine concentrations. This may lead to loss of antidepressant effect and relapse.
How serious is the interaction between Apalutamide and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant response and consider increasing vortioxetine, up to about three times the original dose per labeling for strong inducers, but not above the maximum recommended dose. Reduce the dose back within 14 days if the inducer is stopped.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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