Drug interactions
Apomorphine + Dantrolene
Severity: Moderate
Apomorphine and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine may cause somnolence and sudden sleep onset, and dantrolene adds drowsiness. The combination can increase sedation and the risk of falls or accidents.
What this interaction means in plain words
Apomorphine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for sedation and orthostatic symptoms, and counsel the patient regarding driving and fall risk. Reduce the dose of either drug if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Dantrolene?
MediHelp rates the interaction as moderate. Apomorphine and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine may cause somnolence and sudden sleep onset, and dantrolene adds drowsiness. The combination can increase sedation and the risk of falls or accidents.
How serious is the interaction between Apomorphine and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic symptoms, and counsel the patient regarding driving and fall risk. Reduce the dose of either drug if drowsiness is troublesome.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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