Drug interactions
Apomorphine + Fluconazole
Severity: Moderate
Apomorphine and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so giving them together may raise the risk of torsades de pointes. The risk is higher with electrolyte disturbances, bradycardia, structural heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Apomorphine and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QT prolongation; fluconazole blocks cardiac hERG potassium channels and apomorphine has been associated with QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG if risk factors are present and avoid the combination in patients with congenital long QT.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Fluconazole?
MediHelp rates the interaction as moderate. Apomorphine and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so giving them together may raise the risk of torsades de pointes. The risk is higher with electrolyte disturbances, bradycardia, structural heart disease or other QT-prolonging drugs.
How serious is the interaction between Apomorphine and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat the ECG if risk factors are present and avoid the combination in patients with congenital long QT.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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