Drug interactions
Apomorphine + Melatonin
Severity: Minor
Apomorphine and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin and apomorphine can both cause somnolence, so together they may increase drowsiness. Apomorphine can also cause sudden sleep onset, which makes added sedation more relevant.
What this interaction means in plain words
Apomorphine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apomorphine belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive sedative effects.
What to do
Warn patients about drowsiness and sudden sleep onset and to avoid driving if affected. Review the need for melatonin if daytime somnolence increases.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Melatonin?
MediHelp rates the interaction as minor. Apomorphine and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin and apomorphine can both cause somnolence, so together they may increase drowsiness. Apomorphine can also cause sudden sleep onset, which makes added sedation more relevant.
How serious is the interaction between Apomorphine and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about drowsiness and sudden sleep onset and to avoid driving if affected. Review the need for melatonin if daytime somnolence increases.
What other medicines interact with Melatonin?
MediHelp also lists interactions of Melatonin with, for example, Fluvoxamine, Alfentanil, Belladonna and opium. The full list is on the Melatonin page.
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