Drug interactions
Apomorphine + Mirtazapine
Severity: Moderate
Apomorphine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine has been associated with QT prolongation, and mirtazapine has reports of QT effects, mainly in overdose. Together they may increase arrhythmia risk. Additive sedation and orthostatic hypotension are also possible.
What this interaction means in plain words
Apomorphine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive prolongation of the QT interval and additive CNS and hypotensive effects.
What to do
Obtain a baseline ECG and monitor it in patients with other QT risk factors. Check electrolytes and monitor for orthostatic hypotension and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Mirtazapine?
MediHelp rates the interaction as moderate. Apomorphine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine has been associated with QT prolongation, and mirtazapine has reports of QT effects, mainly in overdose. Together they may increase arrhythmia risk. Additive sedation and orthostatic hypotension are also possible.
How serious is the interaction between Apomorphine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it in patients with other QT risk factors. Check electrolytes and monitor for orthostatic hypotension and sedation.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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