Drug interactions
Apomorphine + Sevoflurane
Severity: Moderate
Apomorphine and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apomorphine can prolong the QT interval and cause hypotension, and sevoflurane also delays repolarization and lowers blood pressure. The combination may raise the risk of arrhythmia and hemodynamic instability.
What this interaction means in plain words
Apomorphine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apomorphine belongs to Central Nervous System; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive QTc prolongation and additive hypotensive effects.
What to do
Obtain a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG and blood pressure intraoperatively and adjust the timing of apomorphine doses around surgery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Apomorphine
- Alosetron + Apomorphine Contraindicated
- Apomorphine + Cisapride Contraindicated
- Apomorphine + Dolasetron Contraindicated
- Apomorphine + Granisetron Contraindicated
- Apomorphine + Netupitant-palonosetron Contraindicated
- Apomorphine + Ondansetron Contraindicated
Frequently asked questions
Can I take Apomorphine with Sevoflurane?
MediHelp rates the interaction as moderate. Apomorphine and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apomorphine can prolong the QT interval and cause hypotension, and sevoflurane also delays repolarization and lowers blood pressure. The combination may raise the risk of arrhythmia and hemodynamic instability.
How serious is the interaction between Apomorphine and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes before anesthesia. Monitor the ECG and blood pressure intraoperatively and adjust the timing of apomorphine doses around surgery.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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