Drug interactions
Aprepitant + Ceritinib
Severity: Moderate
Aprepitant and Ceritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may raise aprepitant concentrations. Higher aprepitant exposure could increase adverse effects such as fatigue, dizziness and gastrointestinal upset.
What this interaction means in plain words
Aprepitant and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Ceritinib belongs to Oncology.
Why it happens
Ceritinib inhibits CYP3A4, reducing the metabolic clearance of aprepitant, which is a CYP3A4 substrate.
What to do
Monitor for aprepitant adverse effects during co-use. Ceritinib is also a CYP3A4 substrate, so watch for ceritinib toxicity because aprepitant is a moderate CYP3A4 inhibitor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Aprepitant with Ceritinib?
MediHelp rates the interaction as moderate. Aprepitant and Ceritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may raise aprepitant concentrations. Higher aprepitant exposure could increase adverse effects such as fatigue, dizziness and gastrointestinal upset.
How serious is the interaction between Aprepitant and Ceritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aprepitant adverse effects during co-use. Ceritinib is also a CYP3A4 substrate, so watch for ceritinib toxicity because aprepitant is a moderate CYP3A4 inhibitor.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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