Drug interactions
Aprepitant + Eletriptan
Severity: Moderate
Aprepitant and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is a sensitive CYP3A4 substrate, and its levels rise markedly with strong inhibitors. A moderate inhibitor like aprepitant may increase exposure and cause more triptan adverse effects such as hypertension, chest symptoms and dizziness.
What this interaction means in plain words
Aprepitant and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Eletriptan belongs to Central Nervous System.
Why it happens
Aprepitant inhibits CYP3A4 metabolism of eletriptan.
What to do
Use the lowest effective eletriptan dose and monitor blood pressure and cardiovascular symptoms. Consider a triptan not dependent on CYP3A4 if the combination is needed repeatedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Aprepitant with Eletriptan?
MediHelp rates the interaction as moderate. Aprepitant and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eletriptan is a sensitive CYP3A4 substrate, and its levels rise markedly with strong inhibitors. A moderate inhibitor like aprepitant may increase exposure and cause more triptan adverse effects such as hypertension, chest symptoms and dizziness.
How serious is the interaction between Aprepitant and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective eletriptan dose and monitor blood pressure and cardiovascular symptoms. Consider a triptan not dependent on CYP3A4 if the combination is needed repeatedly.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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