Drug interactions
Aprepitant + Fluconazole
Severity: Moderate
Aprepitant and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole is a moderate CYP3A4 inhibitor and may raise aprepitant concentrations. Higher aprepitant exposure may lead to more headache, fatigue, constipation or hiccups, though serious toxicity is uncommon.
What this interaction means in plain words
Aprepitant and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4, reducing aprepitant clearance.
What to do
Monitor for aprepitant adverse effects; no routine dose change is required for short courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Frequently asked questions
Can I take Aprepitant with Fluconazole?
MediHelp rates the interaction as moderate. Aprepitant and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole is a moderate CYP3A4 inhibitor and may raise aprepitant concentrations. Higher aprepitant exposure may lead to more headache, fatigue, constipation or hiccups, though serious toxicity is uncommon.
How serious is the interaction between Aprepitant and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aprepitant adverse effects; no routine dose change is required for short courses.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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