Drug interactions
Aprepitant + Gepirone
Severity: Moderate
Aprepitant and Gepirone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant may raise gepirone levels by inhibiting CYP3A4. Higher exposure can increase dizziness, sedation, QT prolongation and other adverse effects.
What this interaction means in plain words
Aprepitant and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Gepirone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated gepirone metabolism by aprepitant.
What to do
Reduce the gepirone dose by 50% when used with a moderate CYP3A4 inhibitor, as labeled. Monitor for dizziness and QT-related symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Aprepitant and Gepirone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Gepirone
- Clarithromycin + Gepirone Contraindicated
- Gepirone + Isocarboxazid Contraindicated
- Gepirone + Itraconazole Contraindicated
- Gepirone + Ketoconazole Contraindicated
- Gepirone + Linezolid Contraindicated
- Gepirone + Phenelzine Contraindicated
Frequently asked questions
Can I take Aprepitant with Gepirone?
MediHelp rates the interaction as moderate. Aprepitant and Gepirone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant may raise gepirone levels by inhibiting CYP3A4. Higher exposure can increase dizziness, sedation, QT prolongation and other adverse effects.
How serious is the interaction between Aprepitant and Gepirone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the gepirone dose by 50% when used with a moderate CYP3A4 inhibitor, as labeled. Monitor for dizziness and QT-related symptoms.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
