Drug interactions
Aprepitant + Idelalisib
Severity: Major
Aprepitant and Idelalisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can markedly raise aprepitant levels. This may increase aprepitant adverse effects. Aprepitant may also modestly affect idelalisib, which is a CYP3A substrate.
What this interaction means in plain words
Aprepitant and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aprepitant belongs to Gastrointestinal Tract; Idelalisib belongs to Oncology.
Why it happens
Idelalisib strongly inhibits CYP3A4, the main clearance pathway of aprepitant.
What to do
Avoid the combination if possible and use an antiemetic not dependent on CYP3A. If used, give a single dose of aprepitant and monitor for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Aprepitant with Idelalisib?
MediHelp rates the interaction as major. Aprepitant and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and can markedly raise aprepitant levels. This may increase aprepitant adverse effects. Aprepitant may also modestly affect idelalisib, which is a CYP3A substrate.
How serious is the interaction between Aprepitant and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible and use an antiemetic not dependent on CYP3A. If used, give a single dose of aprepitant and monitor for adverse effects.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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