Drug interactions
Aprepitant + Linagliptin
Severity: Minor
Aprepitant and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linagliptin is only partly metabolized by CYP3A4 and is mostly eliminated unchanged, so a moderate CYP3A4 inhibitor such as aprepitant is unlikely to matter. The real concern with linagliptin is CYP3A4/P-gp inducers, not inhibitors.
What this interaction means in plain words
Aprepitant and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aprepitant belongs to Gastrointestinal Tract; Linagliptin belongs to Endocrine.
Why it happens
Minor reduction in CYP3A4 metabolism of linagliptin, which has limited clinical impact.
What to do
No adjustment is required; monitor glycemic control as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Aprepitant with Linagliptin?
MediHelp rates the interaction as minor. Aprepitant and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Linagliptin is only partly metabolized by CYP3A4 and is mostly eliminated unchanged, so a moderate CYP3A4 inhibitor such as aprepitant is unlikely to matter. The real concern with linagliptin is CYP3A4/P-gp inducers, not inhibitors.
How serious is the interaction between Aprepitant and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required; monitor glycemic control as usual.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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