Drug interactions
Aprepitant + Lopinavir
Severity: Moderate
Aprepitant and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted lopinavir strongly inhibits CYP3A4 and can substantially increase aprepitant exposure, while aprepitant may modestly affect lopinavir. This may increase aprepitant adverse effects.
What this interaction means in plain words
Aprepitant and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Lopinavir belongs to Anti Virals.
Why it happens
Lopinavir/ritonavir strongly inhibits CYP3A4, reducing aprepitant clearance; aprepitant adds weak reciprocal inhibition.
What to do
Monitor for aprepitant adverse effects and antiretroviral tolerability. Prefer single-dose aprepitant regimens when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Aprepitant with Lopinavir?
MediHelp rates the interaction as moderate. Aprepitant and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted lopinavir strongly inhibits CYP3A4 and can substantially increase aprepitant exposure, while aprepitant may modestly affect lopinavir. This may increase aprepitant adverse effects.
How serious is the interaction between Aprepitant and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aprepitant adverse effects and antiretroviral tolerability. Prefer single-dose aprepitant regimens when feasible.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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