Drug interactions
Aprepitant + Methylprednisolone
Severity: Moderate
Aprepitant and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aprepitant is a moderate CYP3A4 inhibitor and raises methylprednisolone exposure, so systemic corticosteroid effects and adverse effects can be greater. Aprepitant labeling recommends reducing the dose of certain corticosteroids given with it for antiemetic regimens.
What this interaction means in plain words
Aprepitant and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Methylprednisolone belongs to Endocrine.
Why it happens
Aprepitant inhibits CYP3A4-mediated metabolism of methylprednisolone, increasing its plasma concentrations.
What to do
Reduce the methylprednisolone dose when it is given with aprepitant, as recommended in labeling for oral and intravenous corticosteroid use. Monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Frequently asked questions
Can I take Aprepitant with Methylprednisolone?
MediHelp rates the interaction as moderate. Aprepitant and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aprepitant is a moderate CYP3A4 inhibitor and raises methylprednisolone exposure, so systemic corticosteroid effects and adverse effects can be greater. Aprepitant labeling recommends reducing the dose of certain corticosteroids given with it for antiemetic regimens.
How serious is the interaction between Aprepitant and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the methylprednisolone dose when it is given with aprepitant, as recommended in labeling for oral and intravenous corticosteroid use. Monitor for corticosteroid adverse effects such as hyperglycemia and fluid retention.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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