Drug interactions
Aprepitant + Stiripentol
Severity: Moderate
Aprepitant and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4, so its effect on aprepitant exposure is unpredictable. Aprepitant efficacy may fall or adverse effects may rise.
What this interaction means in plain words
Aprepitant and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol has mixed CYP3A4 inhibitory and inducing effects on aprepitant metabolism.
What to do
Monitor for breakthrough emesis and aprepitant adverse effects, and adjust antiemetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Aprepitant with Stiripentol?
MediHelp rates the interaction as moderate. Aprepitant and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol both inhibits and induces CYP3A4, so its effect on aprepitant exposure is unpredictable. Aprepitant efficacy may fall or adverse effects may rise.
How serious is the interaction between Aprepitant and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough emesis and aprepitant adverse effects, and adjust antiemetic therapy accordingly.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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