Drug interactions
Aprepitant + Temsirolimus
Severity: Moderate
Aprepitant and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, so aprepitant may increase their exposure. This could heighten mucositis, myelosuppression, hyperglycemia and other dose-related toxicities.
What this interaction means in plain words
Aprepitant and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aprepitant belongs to Gastrointestinal Tract; Temsirolimus belongs to Oncology.
Why it happens
Aprepitant inhibits CYP3A4, reducing metabolism of temsirolimus and sirolimus.
What to do
Monitor for temsirolimus toxicity, including blood counts, glucose and mucosal effects, when aprepitant is given. Consider an alternative antiemetic if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aprepitant
- Aprepitant + Lomitapide Contraindicated
- Aprepitant + Pimozide Contraindicated
- Aprepitant + Avapritinib Major
- Aprepitant + Bosutinib Major
- Aprepitant + Carbamazepine Major
- Aprepitant + Cobicistat Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Aprepitant with Temsirolimus?
MediHelp rates the interaction as moderate. Aprepitant and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Temsirolimus and its active metabolite sirolimus are CYP3A4 substrates, so aprepitant may increase their exposure. This could heighten mucositis, myelosuppression, hyperglycemia and other dose-related toxicities.
How serious is the interaction between Aprepitant and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus toxicity, including blood counts, glucose and mucosal effects, when aprepitant is given. Consider an alternative antiemetic if toxicity emerges.
What other medicines interact with Aprepitant?
MediHelp also lists interactions of Aprepitant with, for example, Lomitapide, Pimozide, Avapritinib. The full list is on the Aprepitant page.
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