Drug interactions
Aripiprazole + Givosiran
Severity: Moderate
Aripiprazole and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran has been shown to reduce CYP2D6 activity in some patients, and aripiprazole is cleared substantially by CYP2D6. Aripiprazole levels may therefore rise, increasing akathisia, sedation, and other dose-related effects.
What this interaction means in plain words
Aripiprazole and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Aripiprazole belongs to Central Nervous System; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran-associated inhibition of CYP2D6 reduces the metabolism of aripiprazole.
What to do
Monitor for aripiprazole adverse effects such as akathisia and sedation, and reduce the aripiprazole dose if they occur. Consider the same dose reduction used for CYP2D6 poor metabolizers if the effect is pronounced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Aripiprazole
- Aripiprazole + Pimozide Contraindicated
- Aripiprazole + Thioridazine Contraindicated
- Amisulpride + Aripiprazole Major
- Aripiprazole + Arsenic trioxide Major
- Aripiprazole + Calcium / magnesium / potassium / sodium oxybates Major
- Aripiprazole + Carbamazepine Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Aripiprazole with Givosiran?
MediHelp rates the interaction as moderate. Aripiprazole and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran has been shown to reduce CYP2D6 activity in some patients, and aripiprazole is cleared substantially by CYP2D6. Aripiprazole levels may therefore rise, increasing akathisia, sedation, and other dose-related effects.
How serious is the interaction between Aripiprazole and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for aripiprazole adverse effects such as akathisia and sedation, and reduce the aripiprazole dose if they occur. Consider the same dose reduction used for CYP2D6 poor metabolizers if the effect is pronounced.
What other medicines interact with Aripiprazole?
MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.
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