Drug interactions
Armodafinil + Dihydroergotamine
Severity: Moderate
Armodafinil and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak to moderate CYP3A4 inducer and may lower dihydroergotamine exposure, which could reduce its antimigraine effect. The effect is modest and less dangerous than the opposite situation with CYP3A4 inhibitors, which carries ergotism risk.
What this interaction means in plain words
Armodafinil and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Armodafinil induces CYP3A4, increasing the metabolism of dihydroergotamine.
What to do
Monitor for reduced migraine control and consider a higher dose or alternative therapy if efficacy is lost. Review the need for armodafinil if headaches worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Dihydroergotamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Armodafinil
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Armodafinil with Dihydroergotamine?
MediHelp rates the interaction as moderate. Armodafinil and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil is a weak to moderate CYP3A4 inducer and may lower dihydroergotamine exposure, which could reduce its antimigraine effect. The effect is modest and less dangerous than the opposite situation with CYP3A4 inhibitors, which carries ergotism risk.
How serious is the interaction between Armodafinil and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced migraine control and consider a higher dose or alternative therapy if efficacy is lost. Review the need for armodafinil if headaches worsen.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
