Drug interactions
Armodafinil + Duloxetine
Severity: Minor
Armodafinil and Duloxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak inducer of some enzymes and may modestly lower duloxetine exposure. The clinical effect is likely small and rarely requires a change in therapy.
What this interaction means in plain words
Armodafinil and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Why it happens
Possible weak induction of CYP1A2-mediated duloxetine metabolism by armodafinil.
What to do
No routine adjustment; assess antidepressant response and increase duloxetine dose only if efficacy appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Duloxetine?
MediHelp rates the interaction as minor. Armodafinil and Duloxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak inducer of some enzymes and may modestly lower duloxetine exposure. The clinical effect is likely small and rarely requires a change in therapy.
How serious is the interaction between Armodafinil and Duloxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; assess antidepressant response and increase duloxetine dose only if efficacy appears reduced.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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