Drug interactions
Armodafinil + Ergotamine
Severity: Minor
Armodafinil and Ergotamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may reduce ergotamine exposure, which could lessen migraine relief. Lower ergotamine levels are generally less hazardous than higher ones.
What this interaction means in plain words
Armodafinil and Ergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
Armodafinil induces CYP3A4, increasing ergotamine metabolism.
What to do
Monitor for reduced headache control and adjust therapy if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Armodafinil with Ergotamine?
MediHelp rates the interaction as minor. Armodafinil and Ergotamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil may reduce ergotamine exposure, which could lessen migraine relief. Lower ergotamine levels are generally less hazardous than higher ones.
How serious is the interaction between Armodafinil and Ergotamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced headache control and adjust therapy if the response is inadequate.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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