Drug interactions
Armodafinil + Fedratinib
Severity: Moderate
Armodafinil and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is metabolized by CYP3A4, so induction by armodafinil may reduce its exposure and efficacy in myelofibrosis. The combination has not been formally studied.
What this interaction means in plain words
Armodafinil and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Fedratinib belongs to Oncology.
Why it happens
Armodafinil induces CYP3A4, potentially increasing the clearance of fedratinib.
What to do
Monitor spleen response and symptoms, and prefer a non-inducing alternative to armodafinil where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Armodafinil with Fedratinib?
MediHelp rates the interaction as moderate. Armodafinil and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is metabolized by CYP3A4, so induction by armodafinil may reduce its exposure and efficacy in myelofibrosis. The combination has not been formally studied.
How serious is the interaction between Armodafinil and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor spleen response and symptoms, and prefer a non-inducing alternative to armodafinil where possible.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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