Drug interactions
Armodafinil + Finerenone
Severity: Moderate
Armodafinil and Finerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is a CYP3A4 substrate, and induction by armodafinil may lower its exposure and reduce renal and cardiovascular benefit. Moderate inducers have a smaller effect than strong inducers.
What this interaction means in plain words
Armodafinil and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Finerenone belongs to Cardiovascular.
Why it happens
Armodafinil induces CYP3A4, increasing the metabolism of finerenone.
What to do
Monitor serum potassium and renal function, and adjust finerenone dosing based on response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Armodafinil with Finerenone?
MediHelp rates the interaction as moderate. Armodafinil and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Finerenone is a CYP3A4 substrate, and induction by armodafinil may lower its exposure and reduce renal and cardiovascular benefit. Moderate inducers have a smaller effect than strong inducers.
How serious is the interaction between Armodafinil and Finerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, and adjust finerenone dosing based on response.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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