Drug interactions
Armodafinil + Fluconazole
Severity: Minor
Armodafinil and Fluconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole may raise armodafinil concentrations because armodafinil is partly cleared by CYP3A4. Clinically important effects are unlikely but may include insomnia, anxiety or headache.
What this interaction means in plain words
Armodafinil and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP3A4, reducing armodafinil metabolism.
What to do
No empirical adjustment is needed. Monitor for increased stimulant adverse effects and reduce the armodafinil dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Fluconazole?
MediHelp rates the interaction as minor. Armodafinil and Fluconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluconazole may raise armodafinil concentrations because armodafinil is partly cleared by CYP3A4. Clinically important effects are unlikely but may include insomnia, anxiety or headache.
How serious is the interaction between Armodafinil and Fluconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical adjustment is needed. Monitor for increased stimulant adverse effects and reduce the armodafinil dose if they occur.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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