Drug interactions
Armodafinil + Idelalisib
Severity: Moderate
Armodafinil and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may increase armodafinil exposure, intensifying stimulant adverse effects. Armodafinil is not a sensitive CYP3A substrate, so the effect is likely modest.
What this interaction means in plain words
Armodafinil and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Idelalisib belongs to Oncology.
Why it happens
Idelalisib inhibits CYP3A4, reducing the metabolism of armodafinil.
What to do
Monitor for insomnia, anxiety, headache, rash and increased blood pressure or heart rate, and reduce the armodafinil dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Armodafinil with Idelalisib?
MediHelp rates the interaction as moderate. Armodafinil and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may increase armodafinil exposure, intensifying stimulant adverse effects. Armodafinil is not a sensitive CYP3A substrate, so the effect is likely modest.
How serious is the interaction between Armodafinil and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for insomnia, anxiety, headache, rash and increased blood pressure or heart rate, and reduce the armodafinil dose if needed.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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