Drug interactions
Armodafinil + Levoketoconazole
Severity: Moderate
Armodafinil and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and may raise armodafinil concentrations, increasing adverse effects such as headache, anxiety and insomnia. Levoketoconazole also prolongs the QT interval, but this is not related to armodafinil.
What this interaction means in plain words
Armodafinil and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated armodafinil metabolism by levoketoconazole.
What to do
Monitor for stimulant-related adverse effects and reduce the armodafinil dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Armodafinil with Levoketoconazole?
MediHelp rates the interaction as moderate. Armodafinil and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and may raise armodafinil concentrations, increasing adverse effects such as headache, anxiety and insomnia. Levoketoconazole also prolongs the QT interval, but this is not related to armodafinil.
How serious is the interaction between Armodafinil and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for stimulant-related adverse effects and reduce the armodafinil dose if they occur.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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