Drug interactions
Armodafinil + Linagliptin
Severity: Minor
Armodafinil and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP3A4 and P-gp inducers reduce linagliptin exposure and efficacy, whereas armodafinil is only a weak inducer. A modest loss of glycemic control is possible, and the effect would be a decrease rather than an increase in linagliptin levels.
What this interaction means in plain words
Armodafinil and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Linagliptin belongs to Endocrine.
Why it happens
Weak induction of CYP3A4 and P-gp may slightly increase linagliptin clearance.
What to do
Monitor blood glucose and HbA1c after starting armodafinil, and adjust diabetes therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Frequently asked questions
Can I take Armodafinil with Linagliptin?
MediHelp rates the interaction as minor. Armodafinil and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Strong CYP3A4 and P-gp inducers reduce linagliptin exposure and efficacy, whereas armodafinil is only a weak inducer. A modest loss of glycemic control is possible, and the effect would be a decrease rather than an increase in linagliptin levels.
How serious is the interaction between Armodafinil and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting armodafinil, and adjust diabetes therapy if control worsens.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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