Drug interactions
Armodafinil + Lopinavir
Severity: Moderate
Armodafinil and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is a CYP3A4 substrate, and armodafinil's weak induction may lower its concentrations. Subtherapeutic exposure could lead to virologic failure and resistance.
What this interaction means in plain words
Armodafinil and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 induction by armodafinil increases lopinavir clearance.
What to do
Monitor HIV viral load and consider therapeutic drug monitoring of lopinavir when armodafinil is used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Armodafinil with Lopinavir?
MediHelp rates the interaction as moderate. Armodafinil and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir is a CYP3A4 substrate, and armodafinil's weak induction may lower its concentrations. Subtherapeutic exposure could lead to virologic failure and resistance.
How serious is the interaction between Armodafinil and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider therapeutic drug monitoring of lopinavir when armodafinil is used.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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