Drug interactions
Armodafinil + Loratadine
Severity: Minor
Armodafinil and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may modestly lower loratadine exposure. The clinical impact is likely small.
What this interaction means in plain words
Armodafinil and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Loratadine belongs to Respiratory.
Why it happens
Weak induction of CYP3A4-mediated loratadine metabolism by armodafinil.
What to do
No routine adjustment; check for reduced antihistamine effect if symptoms recur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Loratadine?
MediHelp rates the interaction as minor. Armodafinil and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may modestly lower loratadine exposure. The clinical impact is likely small.
How serious is the interaction between Armodafinil and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; check for reduced antihistamine effect if symptoms recur.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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