Drug interactions
Armodafinil + Melatonin
Severity: Minor
Armodafinil and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin promotes sleep while armodafinil promotes wakefulness, so they may blunt each other's intended effects. Armodafinil taken late in the day can impair sleep, and melatonin may reduce its alertness benefit if taken at the wrong time. No serious harm is expected.
What this interaction means in plain words
Armodafinil and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Opposing pharmacodynamic effects on sleep-wake regulation.
What to do
Time armodafinil in the morning and melatonin at the intended bedtime. Review the sleep-wake pattern if either drug seems less effective.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Armodafinil with Melatonin?
MediHelp rates the interaction as minor. Armodafinil and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin promotes sleep while armodafinil promotes wakefulness, so they may blunt each other's intended effects. Armodafinil taken late in the day can impair sleep, and melatonin may reduce its alertness benefit if taken at the wrong time. No serious harm is expected.
How serious is the interaction between Armodafinil and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Time armodafinil in the morning and melatonin at the intended bedtime. Review the sleep-wake pattern if either drug seems less effective.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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