Drug interactions
Armodafinil + Midodrine
Severity: Moderate
Armodafinil and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise blood pressure, armodafinil through sympathomimetic-like CNS stimulation and midodrine through alpha-1 vasoconstriction. Together they may increase the risk of supine hypertension, palpitations or increased heart rate.
What this interaction means in plain words
Armodafinil and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Additive pressor effects from alpha-1 agonism and CNS stimulation.
What to do
Monitor blood pressure, including supine readings, and heart rate when starting or adjusting either drug. Reduce the midodrine dose or avoid late-day dosing if hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Armodafinil with Midodrine?
MediHelp rates the interaction as moderate. Armodafinil and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise blood pressure, armodafinil through sympathomimetic-like CNS stimulation and midodrine through alpha-1 vasoconstriction. Together they may increase the risk of supine hypertension, palpitations or increased heart rate.
How serious is the interaction between Armodafinil and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including supine readings, and heart rate when starting or adjusting either drug. Reduce the midodrine dose or avoid late-day dosing if hypertension occurs.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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