Drug interactions
Armodafinil + Omaveloxolone
Severity: Moderate
Armodafinil and Omaveloxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may reduce omaveloxolone concentrations by inducing CYP3A4. This may reduce therapeutic benefit in Friedreich ataxia. Labeling advises avoiding moderate and strong CYP3A4 inducers.
What this interaction means in plain words
Armodafinil and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Omaveloxolone belongs to Central Nervous System.
Why it happens
CYP3A4 induction by armodafinil accelerates the metabolism of omaveloxolone, a CYP3A4 substrate.
What to do
Avoid the combination if possible by using a non-inducing alternative. If coadministered, monitor for loss of clinical benefit.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Armodafinil with Omaveloxolone?
MediHelp rates the interaction as moderate. Armodafinil and Omaveloxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may reduce omaveloxolone concentrations by inducing CYP3A4. This may reduce therapeutic benefit in Friedreich ataxia. Labeling advises avoiding moderate and strong CYP3A4 inducers.
How serious is the interaction between Armodafinil and Omaveloxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible by using a non-inducing alternative. If coadministered, monitor for loss of clinical benefit.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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