Drug interactions
Armodafinil + Ondansetron
Severity: Minor
Armodafinil and Ondansetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and could slightly lower ondansetron exposure. Because ondansetron is metabolized by multiple pathways, the effect is unlikely to matter clinically.
What this interaction means in plain words
Armodafinil and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Ondansetron belongs to Gastrointestinal Tract.
Why it happens
Weak induction of CYP3A4 (and possibly CYP1A2) by armodafinil may modestly increase ondansetron clearance.
What to do
No dose change is needed; reassess antiemetic response if control appears inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Ondansetron?
MediHelp rates the interaction as minor. Armodafinil and Ondansetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and could slightly lower ondansetron exposure. Because ondansetron is metabolized by multiple pathways, the effect is unlikely to matter clinically.
How serious is the interaction between Armodafinil and Ondansetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; reassess antiemetic response if control appears inadequate.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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