Drug interactions
Armodafinil + Oxycodone
Severity: Minor
Armodafinil and Oxycodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a weak CYP3A4 inducer and may lower oxycodone exposure, possibly reducing analgesia. Its wakefulness effect does not reliably offset opioid respiratory depression.
What this interaction means in plain words
Armodafinil and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Weak CYP3A4 induction by armodafinil may increase oxycodone clearance.
What to do
Monitor analgesic response and adjust the oxycodone dose if pain control worsens. Do not rely on armodafinil to counter opioid sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Oxycodone?
MediHelp rates the interaction as minor. Armodafinil and Oxycodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a weak CYP3A4 inducer and may lower oxycodone exposure, possibly reducing analgesia. Its wakefulness effect does not reliably offset opioid respiratory depression.
How serious is the interaction between Armodafinil and Oxycodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and adjust the oxycodone dose if pain control worsens. Do not rely on armodafinil to counter opioid sedation.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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