Drug interactions
Armodafinil + Ruxolitinib
Severity: Minor
Armodafinil and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ruxolitinib is metabolized mainly by CYP3A4. Armodafinil is a weak CYP3A4 inducer, so ruxolitinib exposure would be expected to decrease slightly rather than increase.
What this interaction means in plain words
Armodafinil and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Ruxolitinib belongs to Oncology.
Why it happens
Weak CYP3A4 induction by armodafinil may modestly increase ruxolitinib metabolism.
What to do
No dose change is needed routinely. Monitor blood counts and clinical response to ruxolitinib as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Armodafinil
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Armodafinil with Ruxolitinib?
MediHelp rates the interaction as minor. Armodafinil and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ruxolitinib is metabolized mainly by CYP3A4. Armodafinil is a weak CYP3A4 inducer, so ruxolitinib exposure would be expected to decrease slightly rather than increase.
How serious is the interaction between Armodafinil and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely. Monitor blood counts and clinical response to ruxolitinib as usual.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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