Drug interactions
Armodafinil + Stiripentol
Severity: Moderate
Armodafinil and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4, and armodafinil is a CYP3A4 substrate and weak inducer, so exposures of either drug may change unpredictably. Effects could include reduced wakefulness benefit or more adverse effects.
What this interaction means in plain words
Armodafinil and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol, combined with weak CYP3A4 induction by armodafinil.
What to do
Monitor clinical response and adverse effects of both drugs, and adjust the armodafinil dose accordingly. Monitor seizure control in patients taking stiripentol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Stiripentol
Frequently asked questions
Can I take Armodafinil with Stiripentol?
MediHelp rates the interaction as moderate. Armodafinil and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol both inhibits and induces CYP3A4, and armodafinil is a CYP3A4 substrate and weak inducer, so exposures of either drug may change unpredictably. Effects could include reduced wakefulness benefit or more adverse effects.
How serious is the interaction between Armodafinil and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects of both drugs, and adjust the armodafinil dose accordingly. Monitor seizure control in patients taking stiripentol.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
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