Drug interactions
Armodafinil + Temsirolimus
Severity: Moderate
Armodafinil and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil may modestly reduce exposure to temsirolimus and its active metabolite sirolimus by inducing CYP3A4, possibly reducing efficacy.
What this interaction means in plain words
Armodafinil and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Temsirolimus belongs to Oncology.
Why it happens
Induction of CYP3A4 metabolism of temsirolimus.
What to do
Monitor for loss of antitumor response and consider an alternative to armodafinil if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Armodafinil
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Armodafinil with Temsirolimus?
MediHelp rates the interaction as moderate. Armodafinil and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil may modestly reduce exposure to temsirolimus and its active metabolite sirolimus by inducing CYP3A4, possibly reducing efficacy.
How serious is the interaction between Armodafinil and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antitumor response and consider an alternative to armodafinil if possible.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Full monographs, dosing and an interaction checker in the MediHelp app
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