Drug interactions
Armodafinil + Trazodone
Severity: Moderate
Armodafinil and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil induces CYP3A4 and may lower trazodone concentrations, potentially reducing its effect. The wakefulness-promoting action of armodafinil may also counter trazodone's sedation.
What this interaction means in plain words
Armodafinil and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Armodafinil belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
CYP3A4 induction by armodafinil increases trazodone clearance.
What to do
Monitor for reduced antidepressant or hypnotic effect and adjust the trazodone dose if needed. Reassess if armodafinil is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Armodafinil and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Trazodone?
MediHelp rates the interaction as moderate. Armodafinil and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Armodafinil induces CYP3A4 and may lower trazodone concentrations, potentially reducing its effect. The wakefulness-promoting action of armodafinil may also counter trazodone's sedation.
How serious is the interaction between Armodafinil and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antidepressant or hypnotic effect and adjust the trazodone dose if needed. Reassess if armodafinil is stopped.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
