Drug interactions
Armodafinil + Trimipramine
Severity: Minor
Armodafinil and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Armodafinil is a wakefulness-promoting drug that may offset sedation from trimipramine. It also has weak CYP3A4 induction and CYP2C19 inhibition, which could alter tricyclic levels, but the clinical relevance is uncertain.
What this interaction means in plain words
Armodafinil and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Armodafinil belongs to Central Nervous System; Trimipramine belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on alertness, with possible minor CYP effects of armodafinil.
What to do
No dose change is routinely needed. Monitor for tricyclic adverse effects and for cardiovascular effects such as raised heart rate or blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Armodafinil
Frequently asked questions
Can I take Armodafinil with Trimipramine?
MediHelp rates the interaction as minor. Armodafinil and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Armodafinil is a wakefulness-promoting drug that may offset sedation from trimipramine. It also has weak CYP3A4 induction and CYP2C19 inhibition, which could alter tricyclic levels, but the clinical relevance is uncertain.
How serious is the interaction between Armodafinil and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor for tricyclic adverse effects and for cardiovascular effects such as raised heart rate or blood pressure.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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