Drug interactions
Dofetilide + Tiotropium-olodaterol
Severity: Major
Dofetilide and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide is a potent QT-prolonging antiarrhythmic with a substantial torsades de pointes risk, and beta2-agonist induced hypokalemia or cardiac stimulation can increase this risk. The combination may precipitate ventricular arrhythmias.
What this interaction means in plain words
Dofetilide and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta2-mediated hypokalemia and cardiac stimulation.
What to do
Maintain normal potassium and magnesium and monitor ECG, particularly QTc, during co-therapy. Consider an alternative bronchodilator if QTc lengthens excessively.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dofetilide and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Dofetilide and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide is a potent QT-prolonging antiarrhythmic with a substantial torsades de pointes risk, and beta2-agonist induced hypokalemia or cardiac stimulation can increase this risk. The combination may precipitate ventricular arrhythmias.
How serious is the interaction between Dofetilide and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain normal potassium and magnesium and monitor ECG, particularly QTc, during co-therapy. Consider an alternative bronchodilator if QTc lengthens excessively.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
