Drug interactions
Ciclesonide + Darunavir
Severity: Moderate
Ciclesonide and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, especially when boosted, inhibits CYP3A4 and can increase ciclesonide exposure. This raises the risk of Cushing's syndrome and adrenal suppression with chronic use.
What this interaction means in plain words
Ciclesonide and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Darunavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by darunavir (and its booster) reduces ciclesonide metabolism.
What to do
Monitor for systemic corticosteroid effects in long-term use. Consider beclomethasone as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Ciclesonide with Darunavir?
MediHelp rates the interaction as moderate. Ciclesonide and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, especially when boosted, inhibits CYP3A4 and can increase ciclesonide exposure. This raises the risk of Cushing's syndrome and adrenal suppression with chronic use.
How serious is the interaction between Ciclesonide and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects in long-term use. Consider beclomethasone as an alternative.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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