Drug interactions
Atogepant + Enzalutamide
Severity: Moderate
Atogepant and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and lowers atogepant exposure, which may reduce migraine prevention efficacy. Labeling advises specific atogepant dosing with CYP3A4 inducers.
What this interaction means in plain words
Atogepant and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atogepant belongs to Central Nervous System; Enzalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 by enzalutamide increases atogepant clearance.
What to do
Use atogepant 30 mg or 60 mg daily as labeled with strong inducers and monitor for loss of migraine control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Enzalutamide?
MediHelp rates the interaction as moderate. Atogepant and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and lowers atogepant exposure, which may reduce migraine prevention efficacy. Labeling advises specific atogepant dosing with CYP3A4 inducers.
How serious is the interaction between Atogepant and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use atogepant 30 mg or 60 mg daily as labeled with strong inducers and monitor for loss of migraine control.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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