Drug interactions
Atogepant + Progesterone
Severity: Minor
Atogepant and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atogepant is a CYP3A4 substrate, and progesterone is at most a weak CYP3A4 inhibitor. Any increase in atogepant exposure is likely small.
What this interaction means in plain words
Atogepant and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Progesterone belongs to Endocrine.
Why it happens
Possible weak CYP3A4 inhibition by progesterone reducing atogepant clearance; not firmly established.
What to do
No dose adjustment is generally needed; monitor for atogepant adverse effects such as constipation and nausea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Progesterone?
MediHelp rates the interaction as minor. Atogepant and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atogepant is a CYP3A4 substrate, and progesterone is at most a weak CYP3A4 inhibitor. Any increase in atogepant exposure is likely small.
How serious is the interaction between Atogepant and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed; monitor for atogepant adverse effects such as constipation and nausea.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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