Drug interactions
Atogepant + Propofol
Severity: Minor
Atogepant and Propofol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is reported to have weak CYP3A4 inhibitory activity in vitro, which could theoretically raise atogepant exposure. Clinical relevance is likely small with a short anesthetic exposure.
What this interaction means in plain words
Atogepant and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Atogepant belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Possible weak inhibition of CYP3A4-mediated metabolism of atogepant by propofol, not well established clinically.
What to do
No dose change is generally needed for short propofol exposure. Monitor for atogepant adverse effects such as nausea or constipation if prolonged infusion is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propofol
Other interactions of Atogepant
- Amobarbital + Atogepant Moderate
- Apalutamide + Atogepant Moderate
- Aprepitant + Atogepant Moderate
- Armodafinil + Atogepant Moderate
- Atogepant + Bosentan Moderate
- Atogepant + Carbamazepine Moderate
Frequently asked questions
Can I take Atogepant with Propofol?
MediHelp rates the interaction as minor. Atogepant and Propofol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propofol is reported to have weak CYP3A4 inhibitory activity in vitro, which could theoretically raise atogepant exposure. Clinical relevance is likely small with a short anesthetic exposure.
How serious is the interaction between Atogepant and Propofol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed for short propofol exposure. Monitor for atogepant adverse effects such as nausea or constipation if prolonged infusion is used.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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