Drug interactions
Avanafil + Clevidipine
Severity: Moderate
Avanafil and Clevidipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and the combination may produce excessive hypotension, dizziness or syncope. The risk is greatest in volume-depleted patients or those on several antihypertensives.
What this interaction means in plain words
Avanafil and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Clevidipine belongs to Cardiovascular.
Why it happens
Additive vasodilation from PDE5 inhibition and L-type calcium channel blockade.
What to do
Monitor blood pressure and orthostatic symptoms when combining; ensure the patient is hemodynamically stable before using avanafil and counsel on rising slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Clevidipine
Frequently asked questions
Can I take Avanafil with Clevidipine?
MediHelp rates the interaction as moderate. Avanafil and Clevidipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and the combination may produce excessive hypotension, dizziness or syncope. The risk is greatest in volume-depleted patients or those on several antihypertensives.
How serious is the interaction between Avanafil and Clevidipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when combining; ensure the patient is hemodynamically stable before using avanafil and counsel on rising slowly.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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