Drug interactions
Avanafil + Crizotinib
Severity: Moderate
Avanafil and Crizotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib is a moderate CYP3A4 inhibitor and may increase avanafil exposure. This raises the risk of hypotension, headache, flushing and priapism.
What this interaction means in plain words
Avanafil and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, reducing the metabolic clearance of avanafil.
What to do
Limit avanafil to 50 mg no more often than once every 24 hours. Monitor for hypotension and other adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Frequently asked questions
Can I take Avanafil with Crizotinib?
MediHelp rates the interaction as moderate. Avanafil and Crizotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Crizotinib is a moderate CYP3A4 inhibitor and may increase avanafil exposure. This raises the risk of hypotension, headache, flushing and priapism.
How serious is the interaction between Avanafil and Crizotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit avanafil to 50 mg no more often than once every 24 hours. Monitor for hypotension and other adverse effects.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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